Enterprise

The Enterprise was the second Explorer-class shuttle air frame completed, and the first one explicitly built for orbital flights.

Destruction:
During TSO-XXX, Enterprise was launched to rendezvous with SpaceLab. During reentry, a issue with the flight controls led to a pilot induced oscillation at 30,000m.

Enterprise flipped sideways and the wings sheared off. The centerbody of the Enterprise continued to flip until the engines pointed towards the ground.

Luckily, by now the shuttle had loss so much velocity that the crew was able to bail out. All 4 crew survived the landing.

The rest of Enterprise impacted the ground short into the mountains behind the KSC.